antibody phospho-aurka t288 /aurkb t232 /aurkc t198  (Cell Signaling Technology Inc)

Journal: EMBO Molecular Medicine

Article Title: Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability

doi: 10.1038/s44321-024-00102-5

Figure Lengend Snippet: ( A ) Tumor volumes for CDC PDX models treated with vehicle control ( n = 9 mice) or CDK9 inhibitor LDC000067 (LDC, n = 10 mice) ( p value = 1.1E-07, two-way ANOVA). Data were presented as the mean ± SD. ( B ) Survival analysis for mice treated with LDC ( n = 10 mice), compared with those treated with vehicle control ( n = 9 mice) ( p value = 3.00E-06, log-rank test). ( C ) Body weight of the CDC1 PDXs. Vehicle control ( n = 9 mice) and LDC ( n = 10 mice). Data were presented as the mean ± SD. ( D ) Ki67, p-AURKA, TPX2, and p-RB1 staining of selected PDX tumors treated with vehicle control or LDC. ( E – H ) Ki67 positive cells per area, a staining score of p-AURKA, TPX2, and p-RB1 respectively, comparing PDX tumors treated with vehicle control or LDC ( n = 5 mice, two-sided t -test, equal variance). .

Article Snippet: The sections were then incubated with antibodies specific to Ki67 (Zsbio Commerce Store, cat #ZA-0502), p-AURKA (Cell Signaling Technology, cat #3079), TPX2 (Cell Signaling Technology, cat #12245), p-RB1 (Cell Signaling Technology, cat #8180), CK19 (Cell Signaling Technology, cat #13902) and PAX8 (Cell Signaling Technology, cat #28556) at 4 °C overnight, respectively.

Techniques: Control, Staining

Journal: EMBO Molecular Medicine

Article Title: Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability

doi: 10.1038/s44321-024-00102-5

Figure Lengend Snippet: Reagents and tools table

Article Snippet: The sections were then incubated with antibodies specific to Ki67 (Zsbio Commerce Store, cat #ZA-0502), p-AURKA (Cell Signaling Technology, cat #3079), TPX2 (Cell Signaling Technology, cat #12245), p-RB1 (Cell Signaling Technology, cat #8180), CK19 (Cell Signaling Technology, cat #13902) and PAX8 (Cell Signaling Technology, cat #28556) at 4 °C overnight, respectively.

Techniques: Sequencing, Drug discovery, Modification, Saline, cDNA Synthesis, Polymer, Software